Subtype	Description	Typical group(s) affected	Common presenting features	Five-year relative survival rate*
Acute lymphoblastic leukemia	Blast cells on peripheral blood smear or bone marrow aspirate	Children and young adults (53% of new cases occur in persons < 20 years)	Symptoms: fever, lethargy, bleeding, musculoskeletal pain or dysfunction	< 50 years: 75% ≥ 50 years: 25%
			Signs: hepatosplenomegaly and lymphadenopathy
Acute myelogenous leukemia	Blast cells on peripheral blood smear or bone marrow aspirate; Auer rods on peripheral smear	Adults (accounts for 80% of acute leukemia in adults)	Symptoms: fever, fatigue, weight loss, bleeding or bruising	< 50 years: 55% ≥ 50 years: 14%
			Signs: hepatosplenomegaly and lymphadenopathy (rare)
Chronic lymphocytic leukemia	Clonal expansion of at least 5,000 B lymphocytes per μL (5.0 × 109 per L) in the peripheral blood	Older adults (85% of new cases occur in persons > 65 years)	Symptoms: 50% of patients are asymptomatic	< 50 years: 94% ≥ 50 years: 83%
			Signs: hepatosplenomegaly and lymphadenopathy
Chronic myelogenous leukemia	Philadelphia chromosome (BCR-ABL1 fusion gene)	Adults	Symptoms: 20% of patients are asymptomatic	< 50 years: 84% ≥ 50 years: 48%
			Signs: splenomegaly