Adults
First-line
Amoxicillin/clavulanate (Augmentin), 875/125 mg every 12 hours
Alternatives
Clindamycin, 300 mg 3 times per day plus ciprofloxacin (Cipro), 500 mg twice per day
Doxycycline, 100 mg twice per day
Penicillin VK, 500 mg 4 times per day plus dicloxacillin, 500 mg 4 times per day
A fluoroquinolone; trimethoprim/sulfamethoxazole, 160/800 mg twice per day; or cefuroxime axetil (Ceftin), 500 mg twice per day plus metronidazole (Flagyl), 250 to 500 mg 4 times per day, or clindamycin, 300 mg 3 times per day
Children
First-line
Amoxicillin/clavulanate, 25 to 45 mg per kg divided every 12 hours
Alternative
Clindamycin, 10 to 25 mg per kg divided every 6 to 8 hours plus trimethoprim/sulfamethoxazole, 8 to 10 mg per kg (trimethoprim component) divided every 12 hours
Pregnant women who are allergic to penicillin
Azithromycin (Zithromax), 250 to 500 mg per day
Close monitoring is needed because of high failure rate