Sign	Underlying pathophysiology
Anorexia nervosa
Amenorrhea	Hypothalamic dysfunction, low fat stores, malnutrition
Arrhythmia	Electrolyte disorders, heart failure, prolonged corrected QT interval
Bradycardia	Heart muscle wasting, associated with arrhythmias and sudden death (common in anorexia nervosa)
Brittle hair and nails	Malnutrition
Edema	Heart muscle wasting, associated with arrhythmias and sudden death (common in anorexia nervosa)
Hyperkeratosis	Malnutrition, vitamin and mineral deficiencies
Hypotension	Malnutrition, dehydration
Hypothermia	Thermoregulatory dysfunction, hypoglycemia, reduced fat tissue
Lanugo (fine, white hairs on the body)	Response to fat loss and hypothermia
Marked weight loss	Self starvation, low caloric intake
Osteoporosis at a young age	Malnutrition
Bulimia nervosa
Dental enamel erosions and gum disease	Recurrent vomiting washes mouth with acid and stomach enzymes; mineral deficiencies
Edema	Laxative abuse, hypoproteinuria, electrolyte imbalances
Parotid gland enlargement	Gastric acid and enzymes from vomiting cause parotid inflammation
Scars or calluses on fingers or hands (Russell sign [knuckle calluses])	Self-induced vomiting
Weight fluctuations; not underweight	Alternating between bingeing and purging