| First line | |
| Selective serotonin reuptake inhibitors | |
| Escitalopram (Lexapro) | $25 ($190) |
| Fluoxetine (Prozac) | $5 ($250) |
| Fluvoxamine for PD | $15 (NA) |
| Paroxetine (Paxil) | $5 ($150) |
| Sertraline (Zoloft) | $10 ($200) |
| Serotonin-norepinephrine reuptake inhibitors | |
| Duloxetine (Cymbalta) for GAD | $50 ($210) |
| Venlafaxine, extended release (Effexor XR) | $15 ($230) |
| Azapirone | |
| Buspirone (Buspar) for GAD | $5 ($87) |
| Second line | |
| Tricyclic antidepressants | |
| Amitriptyline† | $5 (NA) |
| Imipramine (Tofranil)‡ | $10 ($265) |
| Nortriptyline (Pamelor)† | $10 ($725) |
| Antiepileptics | |
| Pregabalin (Lyrica)† for GAD | NA ($145) |
| Antipsychotics | |
| Quetiapine (Seroquel)† for GAD | $15 ($130) |
| Hydroxyzine (Vistaril) | $12 ($200) |
| Third line | |
| Monoamine oxidase inhibitors§ | |
| Isocarboxazid (Marplan)† | NA ($130) |
| Phenelzine (Nardil)† | $20 ($50) |
| Tranylcypromine (Parnate)† | $50 ($185) |
| Augmentation | |
| Benzodiazepines|| | |
| Alprazolam (Xanax) ¶ | $10 ($70) |
| Clonazepam (Klonopin)** | $10 ($70) |
| Diazepam (Valium) for GAD | $10 ($90) |
| Lorazepam (Ativan)‡ | $10 ($300) |
