| Botanicals | |
| Kava (Piper methysticum) | Possible hepatotoxicity, sedation, interference with P450 substrates |
| Lavender oil (Lavandula angustifolia) | Minimal |
| Passionflower (Passiflora incarnata) | Dizziness, sedation, decreased blood pressure |
| St. John's wort (Hypericum perforatum)† | Similar to serotonin reuptake inhibitors, interference with P450 substrates |
| Valerian (Valeriana officinalis) | Headache, gastrointestinal upset |
| Supplements | |
| 5-Hydroxytryptophan† | Gastrointestinal upset, possible eosinophilia-myalgia syndrome |
| Inositol | Nausea, headache |
| l-theanine | May lower blood pressure; may lower effect of stimulant medication |
| l-tryptophan† | Gastrointestinal upset, possible eosinophilia-myalgia syndrome |
| S-adenosyl-l-methionine† | Gastrointestinal upset, mania in patients with bipolar disorder |
| Vitamin B complex | Yellow urine |
