| Adults: 500 mg orally 2 times per day or 250 mg orally 3 times per day Children younger than 3 months and less than 40 kg (89 lb): 25 to 45 mg per kg per day (amoxicillin component), divided every 12 hours Children older than 3 months and 40 kg or more: 30 mg per kg per day, divided every 12 hours
| For impetigo; human or animal bites; and MSSA, Escherichia coli, or Klebsiella infections Common adverse effects: diaper rash, diarrhea, nausea, vaginal mycosis, vomiting Rare adverse effects: agranulocytosis, hepatorenal dysfunction, hypersensitivity reactions, pseudomembranous enterocolitis
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| Adults: 250 to 500 mg IV or IM every 8 hours (500 to 1,500 mg IV or IM every 6 to 8 hours for moderate to severe infections) Children: 25 to 100 mg per kg per day IV or IM in 3 or 4 divided doses
| For MSSA infections and human or animal bites Common adverse effects: diarrhea, drug-induced eosinophilia, pruritus Rare adverse effects: anaphylaxis, colitis, encephalopathy, renal failure, seizure, Stevens-Johnson syndrome
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| | For MSSA infections, impetigo, and human or animal bites; twice-daily dosing is an option Common adverse effect: diarrhea Rare adverse effects: anaphylaxis, angioedema, interstitial nephritis, pseudomembranous enterocolitis, Stevens-Johnson syndrome
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| Adults: 150 to 450 mg orally 4 times per day (300 to 450 mg orally 4 times per day for 5 to 10 days for MRSA infection; 600 mg orally or IV 3 times per day for 7 to 14 days for complicated infections) Children: 16 mg per kg per day in 3 or 4 divided doses (16 to 20 mg per kg per day for more severe infections; 40 mg per kg per day in 3 or 4 divided doses for MRSA infection)
| For impetigo; MSSA, MRSA, and clostridial infections; and human or animal bites Common adverse effects: abdominal pain, diarrhea, nausea, rash Rare adverse effects: agranulocytosis, elevated liver enzyme levels, erythema multiforme, jaundice, pseudomembranous enterocolitis
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| Adults: 125 to 500 mg orally every 6 hours (maximal dosage, 2 g per day) Children less than 40 kg: 12.5 to 50 mg per kg per day divided every 6 hours Children 40 kg or more: 125 to 500 mg every 6 hours
| For MSSA infections Common adverse effects: diarrhea, impetigo, nausea, vomiting Rare adverse effects: anaphylaxis, hemorrhagic colitis, hepatorenal toxicity
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| Adults: 100 mg orally 2 times per day Children 8 years and older and less than 45 kg (100 lb): 4 mg per kg per day in 2 divided doses Children 8 years and older and 45 kg or more: 100 mg orally 2 times per day
| For MRSA infections and human or animal bites; not recommended for children younger than 8 years Common adverse effects: myalgia, photosensitivity Rare adverse effects: Clostridium difficile colitis, hepatotoxicity, pseudotumor cerebri, Stevens-Johnson syndrome
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| | For human or animal bites; not useful in MRSA infections; not recommended for children Common adverse effects: diarrhea, headache, nausea, rash, vomiting Rare adverse effects: agranulocytosis, arrhythmias, hepatorenal failure, tendon rupture
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| | For MRSA impetigo and folliculitis; not recommended for children younger than 2 months Rare adverse effects: burning over application site, pruritus
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| | For MSSA impetigo; not recommended for children younger than 9 months Rare adverse effects: allergy, angioedema, application site irritation
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| | For MRSA infections and human or animal bites; contraindicated in children younger than 2 months Common adverse effects: anorexia, nausea, rash, urticaria, vomiting Rare adverse effects: agranulocytosis, C. difficile colitis, erythema multiforme, hepatic necrosis, hyponatremia, rhabdomyolysis, Stevens-Johnson syndrome
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