Clinical recommendation	Evidence rating	References
Increased exercise does not improve symptoms of constipation in nursing home residents or older adults.	A	8–10
Polyethylene glycol (Miralax) is preferred over lactulose for the treatment of constipation because it is more effective and has fewer adverse effects.	A	29
Linaclotide (Linzess) and lubiprostone (Amitiza) are more effective than placebo for chronic constipation.	B	24, 31
Peripherally acting mu-opioid antagonists are more effective than placebo for chronic opioid-induced constipation.	B	23, 34