Clinical recommendationEvidence ratingReferences
Parents should be educated about the benign and self-limited nature of infantile colic.C13
The probiotic Lactobacillus reuteri (strain DSM 17938) may reduce crying in breastfeeding infants with colic.B22, 23
L. reuteri DSM 17938 should not be given to formula-fed infants with colic.B8
Elimination of allergens (e.g., cow's milk, eggs, fish, peanuts, soy, tree nuts, wheat) from the diet of breastfeeding mothers may relieve colic symptoms.A15, 27
Switching formula-fed infants to a hydrolyzed formula may improve colic symptoms.A27