Clinical recommendation	Evidence rating	References
Consider sarcoidosis in patients with unexplained cough, shortness of breath, or constitutional symptoms, especially in groups with a higher prevalence, such as blacks or Scandinavians.	C	1
Diagnosis of sarcoidosis relies on three criteria: (1) a compatible clinical and radiologic presentation, (2) pathologic evidence of noncaseating granulomas, and (3) exclusion of other diseases with similar findings, such as infections or malignancy.	C	1
Cardiac or neurologic sarcoidosis can result in irreversible or life-threatening disease and often requires aggressive treatment with high-dose corticosteroids.	C	39–42
Treatment is not indicated for patients with asymptomatic stage I or II sarcoidosis because spontaneous resolution is common.	C	1
Treatment with corticosteroids should be considered for patients with significant symptomatic or progressive stage II or III pulmonary disease or serious extrapulmonary disease.	B	1, 47, 48
Patients with refractory or complex cases of sarcoidosis may require additional immunosuppressive therapy.	C	1, 51, 52