Medication*	Initial dosage	Maximum dosage	Cost†	Comments
Anticonvulsants
Pregabalin (Lyrica)	300 mg divided twice daily	600 mg divided twice daily	NA ($370)	NNT = 5 to 8, NNH = 9 to 16‡
Gabapentin (Neurontin)	1,200 mg divided three times daily	3,600 mg divided three times daily	$10 ($330)	NNT = 3, NNH = 4‡
Tricyclic antidepressants
Amitriptyline	10 mg daily at bedtime	150 mg daily at bedtime or divided twice daily	$14 (NA)	NNT = 1 to 3, NNH = 28 (major adverse events), 6 (minor adverse events)‡
Serotonin-norepinephrine reuptake inhibitors
Duloxetine (Cymbalta)	60 mg daily or divided twice daily	120 mg daily or divided twice daily	$32 ($240)	NNT = 5, NNH = 17‡
Venlafaxine	150 mg daily	225 mg daily	$14 ($322)	NNT = 3, NNH = 16
Desvenlafaxine (Pristiq)	200 mg daily	400 mg daily	NA ($560)	NNT = 9, NNH = 6 to 14‡
Opioid-like medications
Tramadol	50 mg every 4 to 6 hours	100 mg every 6 hours (maximum 400 mg per day)	$8 (NA)	NNT = 4, NNH = 8
Tapentadol ER (Nucynta ER)	100 mg twice daily	250 mg twice daily	NA ($520)	NNT = 9 to 10, NNH = 5‡
Topical medications
Lidocaine 5% patch	1 patch daily	3 patches daily	$240 (NA)	NNT = 4
Capsaicin 0.075% cream	Four times daily	NA	NA ($22 per 55-g tube)	NNT = 7
Isosorbide dinitrate spray	30 mg at bedtime applied to bottom of feet	NA	NA	NA
Selective serotonin reuptake inhibitors
Citalopram (Celexa)	10 mg daily	40 mg daily	$6 ($215)	NNT = 7
Paroxetine (Paxil)	10 mg daily	40 mg daily	$9 ($170)	NNT = 7
Escitalopram (Lexapro)	10 mg daily	20 mg daily	$9 ($250)	NNT = 7
Opioids
Oxycodone controlled release§	10 mg twice daily	40 mg twice daily	$175 (NA)	NNT = 6, NNH = 13