System	ACR criteria*	SLICC criteria†
Cardiac/pulmonary	Pleuritis (pleuritic pain or rub, or pleural effusion), or pericarditis (documented by electrocardiography, rub, or pericardial effusion)	Serositis (pleurisy for more than one day, pleural effusion, or pleural rub; pericardial pain more than one day, pericardial effusion, pericardial rub, or pericarditis)
Hematologic	Hemolytic anemia, or leukopenia (< 4,000 cells per mm3), or lymphopenia (< 1,500 cells per mm3), or thrombocytopenia (< 100,000 cells per mm3)	Hemolytic anemia Leukopenia (< 4,000 cells per mm3) more than once or lymphopenia (< 1,000 cells per mm3) more than once Thrombocytopenia (< 100,000 cells per mm3)
Immunologic	Positive ANA result	Positive ANA result
	Elevated anti-dsDNA, anti-Sm, or antiphospholipid antibodies	Elevated anti-dsDNA, anti-Sm, or antiphospholipid antibodies, low complement (C3, C4, CH 50), or direct Coombs test (in the absence of hemolytic anemia)
	Discoid rash	Chronic cutaneous lupus
	Photosensitivity	Nonscarring alopecia
	Oral ulcers or nasal ulcers	Oral ulcers or nasal ulcers
Musculoskeletal	Nonerosive arthritis involving two or more joints	Synovitis involving two or more joints, or tenderness at two or more joints and at least 30 minutes of stiffness in the morning
Neuropsychiatric	Seizure or psychosis	Seizures, psychosis, mononeuritis complex, myelitis, or peripheral or cranial neuropathy
Renal	Persistent proteinuria > 0.5 g per day or > 3+ on urine dipstick testing, or cellular casts	Urinary creatinine (or 24-hour urinary protein) > 500 mg, or red blood cell casts
Skin/mucosal	Malar rash	Acute cutaneous lupus or subacute cutaneous lupus