Therapy		Starting dosage	Target/common dosage	Cost*
Drugs shown to decrease mortality and/or improve symptoms†
Aldosterone antagonists†
	Eplerenone (Inspra)	25 mg once per day	50 mg once per day	$65 ($275)
	Spironolactone (Aldactone)	12.5 mg once per day	25 mg once per day	$10 ($70)
Angiotensin-converting enzyme inhibitors†
	Captopril	6.25 mg (one-half tablet) three times per day	12.5 to 50 mg three times per day	$35 to $150
	Enalapril (Vasotec)	2.5 mg twice per day	10 mg twice per day	$25 ($920)
	Fosinopril	5 to 10 mg once per day	40 mg once per day	$20
	Lisinopril (Prinivil)	5 mg once per day	10 to 20 mg once per day	$9 ($60)
	Perindopril (Aceon)	2 mg once per day	8 to 16 mg once per day	$40 to $125 ($100 to $200)
	Quinapril (Accupril)	5 mg once per day	10 to 20 mg twice per day	$20 ($250)
	Ramipril (Altace)	1.25 mg twice per day	5 mg twice per day	$13 ($300)
	Trandolapril (Mavik)	1 mg once per day	4 mg once per day	$16 ($75)
Angiotensin receptor blockers†
	Candesartan (Atacand)	4 mg once per day	32 mg once per day	$65 ($145)
	Valsartan (Diovan)	40 mg twice per day	160 mg twice per day	$30 ($420)
Beta blockers†
	Bisoprolol (Zebeta)	1.25 mg (one-fourth tablet§) once per day	10 mg once per day	$20 ($175)
	Carvedilol (Coreg)	3.125 mg twice per day	25 mg twice per day	$10 ($266)
	Metoprolol succinate (Toprol XL)	12.5 mg (one-half tablet) once per day	200 mg once per day	$35 ($100)
Angiotensin receptor blocker/neprilysin inhibitor
	Sacubitril/valsartan (Entresto)	49 mg/51 mg twice per day	97 mg/103 mg twice per day	Not available ($425)
Sinus node modulator
	Ivabradine (Corlanor)	5 mg twice per day	7.5 mg twice per day	Not available ($407)
Vasodilators†
	Hydralazine	37.5 mg three times per day	75 mg three times per day	$35
	Isosorbide dinitrate (Isordil)	20 mg three times per day	40 mg three times per day	$180 ($245)
	Isosorbide dinitrate/hydralazine (Bidil)	20 mg/37.5 mg three times per day	40 mg/75 mg three times per day	Not available ($590)
Drugs for symptomatic therapy†
Diuretics (loop)‡§
	Bumetanide	1 mg once per day	1 to 10 mg per dose (maximum 10 mg per day)	$165 for maximum
	Ethacrynic acid (Edecrin)	25 mg once per day	25 to 200 mg per dose (maximum 400 mg per day)	$8,000 ($11,850)
	Furosemide (Lasix)	40 mg once per day	20 to 160 mg per dose (maximum 600 mg per day)	$40 ($420) for maximum
	Torsemide (Demadex)	20 mg once per day	20 to 100 mg per dose (maximum 200 mg per day)	$35 ($980) for maximum
Diuretics (thiazide)‡§
	Hydrochlorothiazide	25 mg once per day	25 to 100 mg once per day	$8
	Metolazone	2.5 mg once per day	2.5 to 10 mg once per day	$30
Inotrope†
	Digoxin (Lanoxin)	0.125 mg once per day	0.125 to 0.375 mg per day	$15 ($230) to $35 ($650)