Clinical condition	Strength of association		Benefit of treatment
	TSH 0.1 to 0.4 mIU per L	TSH < 0.1 mIU per L	TSH 0.1 to 0.4 mIU per L	TSH < 0.1 mIU per L
Adverse effects on cognition	Unclear	Unclear	NA	NA
Adverse effects on quality of life	Unclear	Unclear	NA	Unclear
Atrial fibrillation	Good-quality evidence	Good-quality evidence	NA	Unclear
Heart failure and other adverse cardiovascular effects	Unclear	Limited-quality evidence	NA	Limited-quality evidence
Increased bone fractures	Unclear	Limited-quality evidence	NA	NA
Increased bone turnover markers	Limited-quality evidence	Limited-quality evidence	NA	NA
Mortality	Unclear	Limited-quality evidence	NA	NA
Progression to overt hyperthyroidism	Unclear	Good-quality evidence	NA	NA
Reduced bone mineral density in men or premenopausal women	No	No	NA	NA
Reduced bone mineral density in postmenopausal women	Unclear	Good-quality evidence	Unclear	Limited-quality evidence