| Rapid acting |
| Aspart (Novolog) | 10 to 20 minutes | 40 to 50 minutes | 3 to 5 hours |
| Glulisine (Apidra) | 25 minutes | 45 to 48 minutes | 4 to 5 hours |
| Lispro (Humalog) | 15 to 30 minutes | 0.5 to 2.5 hours | 3 to 6.5 hours |
| Human (Afrezza) | 15 to 30 minutes | 53 minutes | 2.6 hours |
| Short acting |
| Regular (Humulin R) U-100 | 30 to 60 minutes | 2 to 4 hours | 5 to 8 hours |
| Intermediate acting |
| Isophane (NPH; Humulin N) | 1 to 3 hours | 8 hours | 12 to 16 hours |
| Long acting |
| Detemir (Levemir) | 3 to 4 hours | 3 to 9 hours | 6 to 23 hours |
| Glargine (Lantus, Basaglar) | 3 to 4 hours | None | 11 to > 24 hours |
| Glargine (Toujeo Solostar) | 6 hours | None | > 24 hours |
| Ultra–long acting |
| Regular U-500 | 30 minutes | 8 hours | 24 hours |
| Degludec (Tresiba Flextouch) | 0.5 to 1.5 hours | 9 hours | 42 hours |
| Premixed |
| 70% isophane/30% regular (Humulin 70/30) | 30 to 60 minutes | Varies | 10 to 16 hours |
| 70% isophane/30% regular (Novolin 70/30) | 30 to 60 minutes | Varies | 10 to 16 hours |
| 70% aspart protamine/30% aspart (Novolog Mix 70/30) | 5 to 15 minutes | Varies | 10 to 16 hours |
| 50% lispro protamine/50% lispro (Humalog Mix 50/50) | 10 to 15 minutes | Varies | 10 to 16 hours |
| 75% lispro protamine/25% lispro (Humalog Mix 75/25) | 10 to 15 minutes | Varies | 10 to 16 hours |
| 70% degludec/30% aspart (Ryzodeg) | See individual components | | |
