| Abscess | Gradual onset of pain | Tender fluctuant mass |
| Cancer | Pain, bleeding, changes in bowel movements, weight loss | Ulcerating, indurated lesion |
| Condyloma | Possible bleeding; anal intercourse | Verrucous lesions |
| Fissure | Tearing pain with bowel movements | Visible tender fissure |
| Fistula | Soiling, itching | Visible opening of fistula |
| Inflammatory bowel disease | Bloody diarrhea, abdominal pain, family history | Possible fistula; colitis on anoscopy |
| Polyps | Painless bleeding | Polyps on endoscopy |
| Proctalgia fugax | Painful rectum, no bleeding | Normal examination; diagnosis of exclusion |
| Proctitis | Painful rectum, bleeding | Tenderness on digital rectal examination |
| Rectal prolapse | Mass with Valsalva maneuver | Prolapse of rectal mucosa |
| Skin tags | History of hemorrhoids, no bleeding | Tags covered with normal skin |