Initial regimens	Alternative regimens	Pregnancy	Recurrence	Treatment of sex partners
Bacterial vaginosis
Metronidazole (Flagyl), 500 mg orally twice daily for seven days* or Metronidazole 0.75% gel (Metrogel), one full applicator (5 g) intravaginally daily for five days or Clindamycin 2% cream, one full applicator (5 g) intravaginally at bedtime for seven days†	Tinidazole (Tindamax), 2 g orally once daily for two days or Tinidazole, 1 g orally once daily for five days or Clindamycin, 300 mg orally twice daily for seven days or Clindamycin (Cleocin Ovules), 100 mg intra-vaginally at bedtime for three days	Metronidazole, 500 mg orally twice daily for seven days	First recurrence: Retrial of same regimen or Trial of alternative initial regimen Multiple recurrences: Metronidazole 0.75% gel, intravaginally twice weekly for four to six months	Routine treatment of sex partners is not recommended
Vulvovaginal candidiasis
Topical azole therapy‡ (Table 5) or Fluconazole (Diflucan), 150 mg orally, single dose	—	Topical azole therapy applied intravaginally for seven days	To achieve mycologic cure§: Topical azole therapy for seven to 14 days or Fluconazole, 150 mg orally every third day for three doses For maintenance: Oral fluconazole (100 mg, 150 mg, or 200 mg) weekly for six months; consider topical treatment if oral is not feasible	Routine treatment of sex partners is not recommended unless the partner is symptomatic
Trichomoniasis
Metronidazole, 2 g orally, single or divided dose on the same day or Tinidazole, 2 g orally, single dose	Metronidazole, 500 mg orally twice daily for seven days	Metronidazole, 2 g orally, single dose in any stage of pregnancy	Differentiate persistent or recurrent infection from reinfection‖ If metronidazole, 2-g single dose fails: Trial of metronidazole, 500 mg twice daily for seven days If metronidazole, 500 mg twice daily for seven days fails: Trial of metronidazole, 2 g daily for seven days If above regimens fail: Consider susceptibility testing (contact Centers for Disease Control and Prevention)	Concurrent treatment of sex partners is recommended Advise refraining from intercourse until partners are treated and symptom-free