Medication	Indications	Comments
Aspirin (75 to 162 mg per day)1,2,48,49	All patients without contraindications	Decreases rates of nonfatal MI, stroke, and cardiovascular death Use caution in patients with gastrointestinal bleeding
P2Y12 receptor antagonist (e.g., 12 clopidogrel [Plavix], ticagrelor [Brilinta], prasugrel [Effient])1,2,4,49	Patients in whom aspirin is contraindicated or not tolerated Use in combination with aspirin after coronary stent placement	Approved for use in patients with acute coronary syndrome, recent MI, stroke, peripheral arterial disease, or coronary stent placement Use caution in patients with gastrointestinal bleeding
Protease-activated receptor-1 blocker (e.g., vorapaxar [Zontivity])50	Patients with acute coronary syndrome	Reduces rates of cardiovascular death, MI, and post-MI stroke Increases risk of intracranial hemorrhage