Clinical recommendation Evidence rating References
Recommended treatment options for localized prostate cancer, including active surveillance, are based on clinical stage, pathologic grade, prostate-specific antigen level, and comorbidity-adjusted life expectancy. C 15
Radical prostatectomy or external beam radiation therapy should be considered for patients with high-risk localized prostate cancer regardless of comorbidity-adjusted life expectancy. C 15
Brachytherapy is an option for patients with low-risk or intermediate-risk prostate cancer. B 15, 26
Active surveillance is an option for patients with low-risk or very low-risk prostate cancer. C 8, 15, 34