Drug	Physiologic effects	Short-term effects	Long-term effects	Serious drug interactions
Cocaine5,19,24,25	Arrhythmias, hypertension, hyperthermia, tachycardia, tremor	Acute MI, aortic dissection, cerebrovascular accidents (ischemic and hemorrhagic), crack lung (diffuse alveolar damage), seizures, tactile hallucinations (e.g., bugs crawling)	Cardiomyopathy, memory loss, movement disorders, perforated nasal septum, psychiatric disorders	Beta blockers
Methamphetamine26	Arrhythmias, hypertension, hyperthermia, tachypnea	Acute MI, insomnia, psychotic symptoms (e.g., delusions, hallucinations, paranoia), seizure, stroke	Extreme weight loss, impaired verbal learning and motor skills, infectious diseases, psychiatric disorders, tooth decay, violent behavior	None
3,4-methylenedioxy-methamphetamine 25,27	Arrhythmias, distortion of sensory and time perception, hypertension, hyperthermia, increased muscle rigidity	Acute MI, agitation, aortic dissection, bruxism, paranoia, rhabdomyolysis, serotonin syndrome	Memory impairment, psychiatric disorders	Monoamine oxidase inhibitors, ritonavir (Norvir)
Synthetic cannabinoids25,28	Conjunctival injection, death, diaphoresis, dystonia, tachycardia	Acute MI, agitation, hallucinations, psychosis	Hyperemesis syndrome, psychiatric disorders	Sildenafil (Viagra), tricyclic antidepressants, warfarin (Coumadin)
Synthetic cathinones (“bath salts”)29	Arrhythmias, cerebral edema, death, hypertension, hyperthermia, muscle spasms	Acute MI, analgesic effects, dysphoria, paranoia, psychosis, seizures, stroke	Psychiatric disorders, renal failure	Unknown