First-line agents (established efficacy based on evidence)	Second-line agents (probably effective based on evidence)
Divalproex (Depakote)	Amitriptyline
Frovatriptan (Frova)*	Atenolol
Metoprolol	Nadolol (Corgard)
Propranolol	Naratriptan (Amerge)*
Timolol	Venlafaxine
Topiramate (Topamax)	Zolmitriptan (Zomig)*