Outcomes	Anticipated absolute effects		Number of participants (number of studies)	Quality of evidence
	Risk with control	Risk with smectite (95% CI)
Duration of diarrhea	Mean of 32.6 to 118.9 hours	MD = 24.4 fewer hours (17.9 to 30.9)	2,209 (15 RCTs)	Low
Clinical resolution at day 3	342 per 1,000	718 per 1,000 (445 to 1,000; NNT = 2.7 [1.5 to 9.8])	312 (5 RCTs)	Low
Stool frequency	Mean of 1.9 to 3.2 episodes per day	MD = 1.3 fewer episodes per day (0.4 to 2.3)	954 (3 RCTs)	Very low
Stool output	Mean of 90.7 to 118.8 g per kg	MD = 11.37 g per kg decrease (21.94 to 0.79 g per kg)	634 (3 RCTs)	Low
Need for hospitalization	85 per 1,000	79 per 1,000 (64 to 98)	885 (2 RCTs)	Low
Need for intravenous access for rehydration	676 per 1,000	520 per 1,000 (365 to 750)	81 (1 RCT)	Moderate
Adverse effects: constipation	0 per 1,000	61 per 1,000	128 (2 RCTs)	Low