Outcome	Relative risk (95% CI)	Assumed risk: warfarin	Corresponding risk (95% CI): direct oral anticoagulants	Number of participants (number of studies)
All strokes and systemic embolic events	0.81 (0.65 to 1.00)	29 per 1,000	23 per 1,000 (19 to 29)	12,545 (5)
Major bleeding	0.79 (0.59 to 1.04)	55 per 1,000	43 per 1,000 (32 to 57)	12,521 (5)
Gastrointestinal bleeding	1.40 (0.97 to 2.01)	17 per 1,000	24 per 1,000 (17 to 35)	5,678 (2)
Intracranial hemorrhage	0.43 (0.27 to 0.69)	14 per 1,000	6 per 1,000 (4 to 9)	12,521 (5)
All-cause mortality	0.91 (0.78 to 1.05)	78 per 1,000	71 per 1,000 (61 to 82)	9,595 (4)