Treatment	Symptom	No. of trials (no. of participants)	Findings	Strength of evidence
Fluoxetine (selective serotonin reuptake inhibitor)	PTSD symptoms*	4 (835)	Reduced PTSD symptoms SMD = –0.28 (95% CI, –0.42 to –0.14)	● ● ○
	Depression symptoms†	3 (771)	Similar reduction in depression symptoms SMD = –0.20 (95% CI, –0.40 to 0.00)	● ○ ○‡ for no difference
Paroxetine (selective serotonin reuptake inhibitor)	PTSD symptoms*	2 (348)	Reduced PTSD symptoms SMD of –0.56 to –0.44 in individual studies Both studies favored treatment (2 of 2 studies P < .05)	● ● ○
	PTSD symptom remission	2 (348)	Greater PTSD symptom reduction RD of 0.13 and 0.19 across 2 individual studies (1 of 2 studies P < .05)	● ● ○
	Depression symptoms†	2 (348)	Reduced depression symptoms SMD ranged from –0.60 to –0.34 across individual studies Both studies favored treatment (2 of 2 studies P < .05)	● ● ○
Sertraline (selective serotonin reuptake inhibitor)	PTSD symptoms*	7 (1,085)	Reduced PTSD symptoms SMD = –0.20 (95% CI, –0.36 to –0.04)	● ○ ○§
	Depression symptoms†	7 (1,085)	Similar reduction in depression symptoms SMD = –0.14 (95% CI, –0.33 to 0.06)	● ○ ○|| for no difference
Venlafaxine (serotonin-norepinephrine reuptake inhibitor)	PTSD symptoms*	2 (687)	Reduced PTSD symptoms SMD of –0.35 and –0.26 for 2 individual studies	● ● ○
	PTSD symptom remission	2 (687)	Greater PTSD symptom remission RD of 0.12 and 0.15 across individual studies	● ● ○¶
	Depression symptoms†	2 (687)	Reduced depression symptoms Between-group mean difference of –2.6 and –1.6 across individual studies	● ● ○**
Prazosin (alpha blocker)	PTSD symptoms*	3 (117)	Reduced PTSD symptoms SMD = –0.52 (95% CI, –0.90 to –0.14)	● ○ ○
Topiramate (anticonvulsant)	PTSD symptoms*	3 (142)	Reduced PTSD symptoms SMD ranged from –1.85 to –0.38 across individual studies	● ○ ○††
Olanzapine (antipsychotic)	PTSD symptoms*	2 (47)	Reduced PTSD symptoms SMD of –1.15 and –0.96 across individual studies, both significantly favored treatment	● ○ ○
		3 (62)	SMD ranged from –1.15 to 0.89 across individual studies All studies favored treatment (2 of 3 studies P < 0.05)
Risperidone (antipsychotic)	PTSD symptoms*	4 (422)	Reduced PTSD symptoms SMD = –0.26 (95% CI, –0.52 to –0.01)	● ○ ○