Lesion	Location	Characteristics
Cystic lesions
Bartholin duct cyst	Vestibule		Usually unilateral, asymptomatic if small
Bartholin gland abscess	Vestibule		Usually unilateral, painful, erythematous; may be fluctuant
Cyst of the canal of Nuck	Labia majora, mons pubis		Soft, compressible; peritoneum entrapped within round ligament; may mimic inguinal hernia
Epidermal inclusion cyst	Labia majora (usually)		Benign, mobile, nontender; caused by trauma or obstruction of pilosebaceous ducts
Hidradenoma papilliferum	Between labia majora and labia minora		Benign, slow-growing, small nodule (2 mm to 3 cm); arises from apocrine sweat glands
Mucous cyst of the vestibule	Labia minora, vestibule, periclitoral area		Soft, smaller than 2 cm in diameter, smooth surface, superficial location, solitary or multiple, usually asymptomatic
Skene duct cyst	Adjacent to urethral meatus in vestibule		Benign, asymptomatic; if large, may cause urethral obstruction and urinary retention
Solid lesions
Acrochordon	Labia majora		Benign, fleshy, variable size, polypoid in appearance; usually pedunculated but may be sessile
Angiokeratoma	Multicentric		Rare, benign, vascular, variable size and shape, single or multiple; associated with and aggravated by pregnancy; associated with Fabry disease
Fibroma	Labia majora, perineal body, introitus		Firm, asymptomatic; may develop pedicle; may undergo myxomatous degeneration; potential for malignancy
Leiomyoma	Labia majora		Rare; solitary, firm; arises from smooth muscle
Lipoma	Labia majora, clitoris		Benign, slow-growing, sessile or pedunculated
Neurofibroma	Multicentric		Small, fleshy, multiple, polypoid in appearance; associated with von Recklinghausen disease
Squamous cell carcinoma	Multicentric		Related to benign epithelial disease in older women and to human papillomavirus infection in young women