| Conservative management |
| Compression therapy | Standard care; recommended for at least one hour per day at least six days per week to prevent recurrence16,17 |
| Dressings | Recommended to cover ulcers and promote moist wound healing18 |
| Medications |
| Antibiotics | Oral antibiotic treatment is warranted if infection is suspected1 |
| Pentoxifylline | Improves healing with or without compression therapy19 |
| Debridement | May benefit ulcer healing20 |
| Surgical management |
| Endovenous ablation | Early endovenous ablation to correct superficial venous reflux may increase healing rates and prevent recurrence21 |
| Skin grafting | Primary therapy for large ulcers (larger than 25 cm2 [3.9 in2]) or secondary therapy for ulcers that do not heal with standard care22 |
