Condition	Characteristics	Histopathology
Condyloma acuminatum	Single or multiple; pedunculated, smooth, or dome-shaped; located on the dorsal tongue and lingual frenulum	Broad hyperplastic papillary projections with cells demonstrating viral changes, such as koilocytosis, parakeratosis, and increased nuclear atypia
Irritation fibroma	Dome-shaped, smooth papule typically located along the bite line	Mass of fibrous tissue covered by normal squamous mucosa
Oral squamous papilloma	Single exophytic growth located on the ventral tongue	Squamous epithelium arrayed in finger-like projections with surrounding hyperkeratosis
Pyogenic granuloma	Single rapidly growing, friable, red papule usually on the lip or gingival mucosa; may be pedunculated or sessile	Lobular pattern of vascular proliferation with inflammation and edema
Squamous cell carcinoma	Thickened white or red patches, ulcerations, or papules that are usually localized to the lateral tongue	Marked squamous epithelial atypia with nests; keratin pearls; and irregular, infiltrative stromal invasion