Comparisons	All causes of death (95% CI)	Total cardiovascular events (95% CI)	Heart failure–related death or hospitalization (95% CI)	Total myocardial infarctions (95% CI)	Total stroke (95% CI)	ESRD (95% CI)	Quality of evidence
RAS inhibitors vs. beta blockers	RR = 0.89 (0.78 to 1.01)	RR = 0.88 (0.80 to 0.98); ARR = 1.7%; NNT = 59	RR = 0.95 (0.76 to 1.18)	RR = 1.05 (0.86 to 1.27)	RR = 0.75 (0.63 to 0.88); ARR = 1.7%; NNT = 59	Not reported	Low
RAS inhibitors vs. thiazide diuretics	RR = 1.00 (0.94 to 1.07)	RR = 1.05 (1.00 to 1.11)	RR = 1.19 (1.07 to 1.31); ARI = 1.1%; NNH = 91	RR = 0.93 (0.86 to 1.01)	RR = 1.14 (1.02 to 1.28); ARI = 0.6%; NNH = 167	RR = 1.10 (0.88 to 1.37)	Low to moderate
RAS inhibitors vs. calcium channel blockers	RR = 1.03 (0.98 to 1.09)	RR = 0.98 (0.93 to 1.02)	RR = 0.83 (0.77 to 0.90); ARR = 1.2%; NNT = 83	RR = 1.01 (0.93 to 1.09)	RR = 1.19 (1.08 to 1.32); ARI = 0.7%; NNH = 143	RR = 0.88 (0.74 to 1.05)	Low to moderate