Clinical recommendation	Evidence rating	Comments
In settings other than the intensive care unit, the quick Sequential Organ Failure Assessment (https://www.mdcalc.com/qsofa-quick-sofa-score-sepsis) can help clinicians recognize possible sepsis early in the evaluation.9,12–14	B	Validation studies and retrospective analysis of observational studies
Sepsis care protocols decrease sepsis-related mortality and should be implemented in all medical facilities.21–24	B	Multiple prospective cohort trials
Patients with sepsis should complete the sepsis bundle (fluid resuscitation, antibiotics, lactate measurement, and cultures) within three hours of presentation.24–27	B	Systematic reviews and retrospective trials
As part of fluid resuscitation, patients with sepsis should receive an intravenous crystalloid at 30 mL per kg.21	C	Expert consensus guideline
Norepinephrine is the first-line vasopressor agent for patients with septic shock if initial fluid resuscitation fails to restore mean arterial pressure to 65 mm Hg or greater.21,28,29	A	Multiple studies with head-to-head comparisons of norepinephrine and other vasopressors and a meta-analysis showing that norepinephrine reduces sepsis-related mortality