Laboratory Score56 (requires CRP, PCT)		Step-by-Step43 (requires CRP, PCT)	Rochester Criteria40 (CRP, PCT not required)
If ill-appearing: high risk		Assess the following in the order shown:  If ill-appearing: high risk  If 21 days or younger: high risk  If leukocyturia is present: high risk  If PCT ≥ 0.5 ng per mL: high risk  If CRP > 20 mg per L: intermediate risk (treat as high risk)  If absolute neutrophil count > 10,000 per mm3 (10.0 × 109 per L): intermediate risk (treat as high risk) If none of the criteria apply, treat as low risk	If ill-appearing: high risk If signs of soft tissue infection, skeletal infection, or ear infection: high risk Obtain complete blood count with differential and microscopic urinalysis  If WBC count ≥ 15,000 per mm3 (15.0 × 109 per L): high risk If WBC count ≤ 5,000 per mm3 (5.0 × 109 per L): high risk  If bands ≥ 1,500 per mm3 (1.5 × 109 per L): high risk  If urine WBC count per high-power field ≥ 10: high risk If none of the criteria apply, treat as low risk
Obtain PCT and CRP measurements and urine dipstick
PCT < 0.5 ng per mL:	0 points
PCT = 0.5 to 1.9 ng per mL:	2 points
PCT ≥ 2 ng per mL:	4 points
CRP < 40 mg per L:	0 points
CRP = 40 to 99 mg per L:	2 points
CRP ≥ 100 mg per L:	4 points
Urine dipstick with leukocyte esterase, nitrites, or both:	1 point
If total score is 3 or more, treat as high risk; otherwise treat as low risk