Patient factors	Antibiotic regimen*
No risk factors for methicillin-resistant Staphylococcus aureus or Pseudomonas aeruginosa† and No comorbidities listed below	Amoxicillin, 1,000 mg every 8 hours  or Doxycycline, 100 mg every 12 hours  or Macrolide if local pneumococcal resistance < 25%:  Azithromycin (Zithromax), 500 mg on day 1, then 250 mg per day  or  Clarithromycin (Biaxin), 500 mg every 12 hours  or  Extended-release clarithromycin (Biaxin XL), 1,000 mg per day
Comorbidities: alcoholism; asplenia; diabetes mellitus; malignancy; or chronic heart, lung, liver, or kidney disease	Combination of: Amoxicillin/clavulanate (Augmentin), 500 mg/125 mg every 8 hours, 875 mg/125 mg every 12 hours, or 2,000 mg/125 mg every 12 hours  or Cefpodoxime, 200 mg every 12 hours  or Cefuroxime axetil, 500 mg every 12 hours PLUS Azithromycin, 500 mg on day 1, then 250 mg per day  or Clarithromycin, 500 mg every 12 hours  or Doxycycline, 100 mg every 12 hours  or Extended-release clarithromycin, 1,000 mg per day OR Monotherapy with a respiratory fluoroquinolone: Gemifloxacin (Factive), 320 mg per day  or Levofloxacin (Levaquin), 750 mg per day  or Moxifloxacin (Avelox), 400 mg per day