Agent and dosing	Comments/pregnancy safety
Ceftazidime/avibactam (Avycaz), 2.5 g every 8 hours	Newer agent with limited evidence; cost and availability limit usage; uncertain pregnancy safety
Ceftolozane/tazobactam (Zerbaxa), 1.5 g every 8 hours	Newer agent with limited evidence; cost and availability limit usage; uncertain pregnancy safety
Ertapenem (Invanz), 1 g once daily	May use during pregnancy; useful dosing for outpatients; increased resistance among some extended-spectrum beta-lactamase–producing organisms, use when susceptible
Imipenem/cilastatin (Primaxin), 500 mg every 6 hours	Uncertain pregnancy safety
Meropenem (Merrem IV), 1 g every 8 hours	Uncertain pregnancy safety
Meropenem/vaborbactam (Vabomere), 2 g/2 g every 8 hours	Newer agent with limited evidence; cost and availability limit usage; uncertain pregnancy safety
Piperacillin/tazobactam (Zosyn), 3.375 to 4.5 g every 6 hours	May use during pregnancy; increased resistance among some extended-spectrum beta-lactamase–producing organisms, resistance can develop during treatment; use 4.5-g dosage when Pseudomonas aeruginosa is suspected
Plazomicin (Zemdri), 15 mg per kg once daily	Newer agent with limited evidence; cost and availability limit usage; uncertain pregnancy safety