| Fibrates | | | | | | |
| Fenofibrate (Tricor), 40 to 160 mg per day | $15 ($18) for 30 48-mg tablets | 25 to 50 | 5 to 20 | Variable | No | First-line therapy to reduce risk of pancreatitis; fenofibrate preferred if in combination with a statin to reduce the risk of myopathy |
| Gemfibrozil (Lopid), 600 mg twice per day | $16 ($404) for 60 600-mg tablets |
| Omega-3 fatty acids (DHA plus EPA) | | | | | | |
| OTC, 2 to 4 g per day | $30 for 400 1-g capsules† | 20 to 50 | Increase to no change | 5 to 10 increase to no change | No | OTC supplements have variable amounts of EPA plus DHA |
| Prescription (Lovaza), 2 to 4 g per day | $30 ($300) for 120 1-g capsules |
| Icosapent (Vascepa; purified EPA), 2 to 4 g per day | — ($270) for 120 1-g capsules | 20 to 50 | Increase to no change | 5 to 10 increase to no change | Yes; NNT = 111 to prevent one cardiovascular death over five years | Icosapent reduces cardiovascular events in patients with hypertriglyceridemia and established CVD who are already taking statins |
| Statins | | | | | | |
| Atorvastatin (Lipitor), 10 to 80 mg per day | $15 ($330) for 30 10-mg tablets | 10 to 20 | 5 to 15 | 18 to 55 decrease | Yes; NNT = 83 to prevent one all-cause death over five years in patients with known CVD (secondary prevention) | For those at high risk of CVD or for secondary prevention; adding statins should be considered in patients with hypertriglyceridemia and borderline to intermediate risk of CVD; not first-line therapy to reduce risk of pancreatitis in patients with severe hypertriglyceridemia |
| Fluvastatin (Lescol ER), 20 to 80 mg per day | $40 for 30 20-mg tablets ($70 for 30 80-mg tablets) |
| Lovastatin (Altoprev ER), 10 to 80 mg per day | $10 ($810) for 30 20-mg tablets |
| Pravastatin (Pravachol), 10 to 80 mg per day | $10 ($175) for 30 40-mg tablets |
| Rosuvastatin (Crestor), 10 to 40 mg per day | $15 ($245) for 30 10-mg tablets |
| Simvastatin (Zocor), 5 to 80 mg per day | $20 ($150) for 30 10-mg tablets |
| Pitavastatin (Livalo), 1 to 4 mg per day | — ($300) for 30 2-mg tablets |
| Niacin, 2 g per day | | | | | | |
| OTC immediate release | $11 for 120 500-mg tablets* | 10 to 35 | 10 to 40 | 5 to 20 decrease | No | Generally not recommended; adverse effects limit tolerability; patients taking ER formulations should be monitored for hepatotoxicity |
| Prescription (Niaspan ER) | $25 ($475) for 60 1-g tablets |
