Clinical recommendation	Evidence rating	Comments
For patients without signs or symptoms and a specific clinical diagnosis, treat the assumed condition empirically for four to eight weeks and reevaluate symptoms.4,11	C	Usual practice, case series, and expert opinion
Identify patients at high risk of infection or malignancy by the presence of findings such as weight loss, objective fever, or lymphadenopathy.2,18	C	Usual practice, case series, case reports, and expert opinion
Reassure and clinically monitor patients who complete a basic evaluation and are unlikely to have a serious underlying cause of their night sweats.1–4	C	Limited epidemiologic data, expert opinion, and usual practice