Preparation	Common formulations	Dosing
Vaginal creams
Conjugated estrogen (Premarin)	0.625 mg per 1 g of cream	Apply 0.5 to 2 g of cream intravaginally once per day for 21 days, then stop for seven days or apply 0.5 g intravaginally twice per week (generally start with 0.5-g dose)
Estradiol (Estrace)	100 mcg per 1 g of cream	Apply 0.5 to 4 g of cream intravaginally once per day for two weeks, then reduce to 0.5 g twice per week
Vaginal tablet
Estradiol (Imvexxy, Vagifem, Yuvafem)	Vagifem and Yuvafem: 10 mcg per tablet Imvexxy: 4 or 10 mcg per tablet	Insert tablet into vagina once per day for two weeks, then reduce to twice per week
Vaginal ring
Estradiol (Estring)	2-mg ring, released as 7.5 mcg per day over 90 days	Insert ring into vagina; replace every 90 days