MedicationFormulationDuration of actionStarting and maximum dosageEstimated cost of starting dosage*
Atomoxetine (Strattera)10 mg, 18 mg, 25 mg, 40 mg, 60 mg, 80 mg, 100 mg24 hours≤ 70 kg (154 lb):
Starting: 0.5 mg per kg once daily for three days, then increase to 1.2 mg per kg per day
Maximum: 1.4 mg per kg per day
> 70 kg:
Starting: 40 mg per day for three days, then increase to 80 mg per day
Maximum: 100 mg per day [corrected]
$40 ($395)
Adverse effects and precautions
Common: decreased appetite, gastrointestinal upset; growth delays (first 2 years; return after 2 to 3 years); increased blood pressure; increased heart rate; somnolence
Rare/serious: hepatotoxicity; suicidal thoughts
Caution: avoid rapid dose increases
Clonidine ER (Kapvay)0.1 mg24 hoursStarting: 0.1 mg at bedtime
Maximum: 0.1 to 0.2 mg two times per day
$20 ($225)
Guanfacine ER (Intuniv)1 mg to 4 mg24 hoursStarting: 1 mg per day, then increase by 1 mg per week
Maximum: 4 mg for 6 to 12 years of age; 7 mg for 13 to 17 years of age
$6 ($290)
Adverse effects and precautions
Common: abdominal pain; bradycardia; dizziness; dry mouth; headache; hypotension; irritability; somnolence
Caution: do not stop abruptly; must taper off