Original medication	Added medication	Outcome	Difference	Evidence quality
Fluoxetine (Prozac), 20 mg daily	Mianserin (not available in the United States), 60 mg daily	Remission rate (HAM-D score < 8)	NNT = 4 (95% CI, 1.3 to 59)	Low (1 study, n = 70)
		Response rate (≥ 50% HAM-D score reduction)	NNT = 4 (95% CI, 1.5 to 91)	Moderate (1 study, n = 70)
		Drop-out rate	Not significant	Low (1 study, n = 70)
Various	Quetiapine (Seroquel), 150 to 300 mg daily	Remission rate (MADRS score < 9)	NNT = 9 (95% CI, 7 to 19)	Moderate (3 studies, n = 977)
		Response rate (≥ 50% MADRS reduction)	NNT = 9 (95% CI, 6 to 25)	Moderate (3 studies, n = 977)
		Drop-out rate	Not significant	Moderate (3 studies, n = 977)
Various	Cariprazine (Vraylar), 1 to 4.5 mg daily	Remission rate (MADRS score < 10)	Not significant	Moderate (1 study, n = 808)
		Response rate (50% MADRS reduction)	NNT = 10 (95% CI, 5 to 37)	Moderate (1 study, n = 808)
		Drop-out rate	NNH = 13 (95% CI, 6 to 53)	Moderate (1 study, n = 821)
Various	Ziprasidone (Geodon), 40 to 160 mg daily	Remission rate (clinician rated)	Not significant	Moderate (2 studies, n = 199)
		Response rate (≥ 50% reduction in MADRS/HAM-D score)	NNT = 7 (95% CI, 3 to 77)	Moderate (2 studies, n = 199)
		Drop-out rate	NNH = 8 (95% CI, 3 to 500)	Moderate (2 studies, n = 199)