Recommendation	Grade	Certainty of evidence
Adults diagnosed as prefrail and frail should be offered a multicomponent physical activity program.	Strong	Moderate
Health care professionals are strongly encouraged to refer older adults with frailty to physical activity programs with a progressive resistance training component.	Strong	Moderate
A comprehensive care plan should address polypharmacy, management of sarcopenia, treatable causes of weight loss, and causes of fatigue (i.e., depression, anemia, hypotension, hypothyroidism, and vitamin B12 deficiency).	Strong	Very low
Older adults diagnosed as frail may be offered social support as needed to address unmet needs and encourage adherence to their individualized care plan.	Strong	Very low
Cognitive or problem-solving therapy is not systematically recommended for the treatment of frailty.	Consensus-based recommendation	Very low
Vitamin D supplementation is not recommended for the treatment of frailty unless vitamin D deficiency is present.	Consensus-based recommendation	Very low
Hormone therapy is not recommended for the treatment of frailty.	Consensus-based recommendation	Very low
Where appropriate, patients with advanced frailty should be referred to a geriatrician.	Consensus-based recommendation	No available data by systematic review
Health care professionals may offer nutritional or protein supplementation paired with physical activity.	Conditional	Low
Supplementation can be considered for older adults with frailty when weight loss or under-nutrition has been diagnosed.	Conditional	Very low