Frailty phenotype variables	Diagnostic criteria
Weight loss (in the past 12 months)	Self-reported loss of 10 lb (4.5 kg) Documented weight loss of ≥ 5% of total body weight
Gait speed (walking 15 feet)	Men (height in inches):  ≤ 68: ≤ 7 seconds  > 68: ≤ 6 seconds Women (height in inches):  ≤ 62.5: ≤ 7 seconds  > 62.5: ≤ 6 seconds
Grip strength (measured with a dynamometer)	Men (body mass index [kg per m2]; grip strength):  ≤ 24: ≥ 64 lb (29 kg)  24.1 to 26: ≥ 66 lb (30 kg)  26.1 to 28: ≥ 66 lb  > 28: ≥ 70.5 lb (32 kg) Women (body mass index [kg per m2]; grip strength):  ≤ 23: ≥ 37.5 lb (17 kg)  23.1 to 26: ≥ 38 lb (17.3 kg)  26.1 to 29: ≥ 39.5 lb (18 kg)  > 29: ≥ 46 lb (21 kg)
Physical exhaustion (Center for Epidemiological Studies Depression Scale)	Patients respond to the following questions:  I felt that everything I did was an effort in the past week.  I could not get going in the past week. Score 0 to 3 (0 = rarely or none of the time; 1 = some or a little of the time; 2 = a moderate amount of the time; 3 = most or all of the time) Scoring 2 or 3 on either question meets the criteria for frailty.
Low energy expenditure (per the Minnesota Leisure Time Physical Activity Questionnaire)	Men: < 383 kcals per week Women: < 270 kcals per week