Organ system	Symptoms/physical findings
Autonomic27,28	Neurally mediated hypotension/syncope Orthostatic intolerance Postural orthostatic tachycardia syndrome
Cardiovascular29	Low progressive aortic root dilation Mitral valve prolapse/insufficiency
Gastrointestinal22	Chronic/recurrent gastritis Defecatory dysfunction Delayed gastric emptying Delayed small bowel and colonic transit Dysphagia Dysphonia Gastroesophageal reflux Hiatal hernia Unexplained abdominal pain Various food intolerances Visceroptosis (prolapse of the abdominal viscera)
Gynecologic26,30	Disabling dysmenorrhea Dyspareunia Menorrhagia/metrorrhagia Pelvic organ prolapse Urinary stress incontinence
Mucocutaneous31	Atrophic scars Easy bruising Gingival inflammation/recessions Hernias (inguinal/umbilical/incisional) Hypoplastic lingual frenulum Keratosis pilaris Light blue sclerae Mildly hyperextensible skin Resistance to local anesthetic drugs Velvety/silky/soft skin texture
Musculoskeletal2,32–34	Chronic pain Chronic/recurrent noninflammatory joint pain Early osteoarthritis Fibromyalgia Flatfoot Generalized joint hypermobility High arched/narrow palate Involuntary muscle contractions Marfanoid habitus (ratio of arm span to height > 1.05) Mild scoliosis, dorsal hyperkyphosis, lumbar hyperlordosis Myofascial pain Nonpostmenopausal reduced bone mass Nonsurgical pectus excavatum Recurrent dislocations (e.g., hips, shoulders, temporomandibular, fingers) Recurrent myalgias and cramps Recurrent soft tissue lesions Temporomandibular joint dysfunction
Neurologic32,34,35	Clumsiness Headache and migraines Impaired memory and concentration Sleep disturbances Somatosensory/central sensitization
Ocular36	Myopia and/or strabismus Palpebral ptosis
Psychological23,37,38	Attention-deficit/hyperactivity disorder Chronic fatigue/chronic fatigue syndrome Depression Generalized anxiety Obsessive-compulsive disorder Panic attacks Phobias, kinesiophobia