Symptoms and physical examination findings
	Classic KD2,6	MIS-C7
Cardiovascular	Tachycardia	Tachycardia
	Cardiogenic shock rare	Cardiogenic shock
Constitutional	Fever	Fever
Dermatologic	Rash	Rash
	Extremity changes	Extremity changes uncommon
Gastrointestinal	Vomiting	Vomiting
	Diarrhea	Diarrhea
		Abdominal pain
Head, ears, eyes, nose, throat	Conjunctivitis	Findings uncommon
	Oral mucous membrane changes
	Cervical lymphadenopathy
Neurocognitive	Irritability	Irritability
	Headache and lethargy uncommon	Headache
		Lethargy
Laboratory and study findings (median, interquartile range)11
	Classic KD	MIS-C
Complete blood count
Total white blood cell count	13,400 per μL (13.4 × 109 per L)	17,000 per μL (17 × 109 per L)
	Range: 10,500 to 17,300 per μL (10.5 to 17.3 × 109 per L)	Range: 12,000 to 22,000 per μL (12 to 22 × 109 per L)
Neutrophil count	7,200 per μL (7.2 × 109 per L)	13,000 per μL (13 × 109 per L)
	Range: 5,100 to 9,900 per μL (5.1 to 9.9 × 109 per L)	Range: 10,000 to 19,000 per μL (10 to 19 × 109 per L)
Lymphocyte count	2,800 per μL (2.8 × 109 per L)	800 per μL (0.8 × 109 per L)
	Range: 1,500 to 4,400 per μL (1.5 to 4.4 × 109 per L)	Range: 500 to 1,500 per μL (0.5 to 1.5 × 109 per L)
Hemoglobin	11.1 g per dL (111 g per L)	9.2 g per dL (92 g per L)
	Range: 10.5 to 11.9 g per dL (105 to 119 g per L)	Range: 8.3 to 10.3 g per dL (83 to 103 g per L)
Platelet count	365,000 per μL (365 × 109 per L)	151,000 per μL (151 × 109 per L)
	Range: 288,000 to 462,000 per μL (288 to 462 × 109 per L)	Range: 104,000 to 210,000 per μL (104 to 210 × 109 per L)
Inflammatory markers
Erythrocyte sedimentation rate	Mild to moderate elevation	Marked elevation
C-reactive protein	6.7 mg per dL (67.0 mg per L)	22 mg per dL (220 mg per L)
	Range: 4.0 to 15.0 mg per dL (40 to 150 mg per L)	Range: 15.6 to 33.8 mg per dL (156 to 338 mg per L)
d dimer	1,650 ng per mL	3,578 ng per mL
	Range: 970 to 2,660 ng per mL	Range: 2,085 to 8,235 ng per mL
Ferritin	200 ng per mL (200 mcg per L)	610 ng per mL (610 mcg per L)
	Range: 143 to 243 ng per mL (143 to 243 mcg per L)	Range: 359 to 1,280 ng per mL (359 to 1,280 mcg per L)
Metabolic panel
Albumin	3.8 g per dL (38 g per L)	2.4 g per dL (24 g per L)
	Range: 3.5 to 4.1 g per dL (35 to 41 g per L)	Range: 2.1 to 2.7 g per dL (21 to 27 g per L)
Alanine transaminase	42 U per L (0.7 μkat per L)	42 U per L (0.7 μkat per L)
	Range: 24 to 112 U per L (0.40 to 1.87 μkat per L)	Range: 26 to 95 U per L (0.43 to 1.59 μkat per L)
Cardiac biomarkers
Troponin	10 ng per L (0.01 mcg per L)	45 ng per L (0.045 mcg per L)
	Range: 10 to 20 ng per L (0.01 to 0.02 mcg per L)	Range: 8 to 294 ng per L (0.008 to 0.294 mcg per L)
N-terminal pro–B-type natriuretic peptide	41 pg per mL (41 ng per L)	788 pg per mL (788 ng per L)
	Range: 12 to 102 pg per mL (12 to 102 ng per L)	Range: 174 to 10,548 pg per mL (174 to 10,548 ng per L)
Echocardiography	Coronary artery dilation and aneurysms	Coronary artery dilation and aneurysms
	Valvular dysfunction	Ventricular dysfunction
	Aortic root dilation
	Ventricular dysfunction rare