Headache subtype	Diagnostic criteria	Nonpharmacologic treatment options	Pharmacologic treatment options
Tension-type	≥ 10 headaches lasting 30 minutes to 7 days plus two of the following:  Mild to moderate severity  Squeezing, tightening quality  Bilateral/global symptoms Typically not associated with nausea, vomiting, or autonomic symptoms	Physical therapy	Acute relief:  Acetaminophen, ibuprofen Preventive:  Amitriptyline
Migraine	Episodic: < 15 headache days in 30 days Chronic: ≥ 15 headache days in 30 days ≥ 5 headaches lasting 4 to 72 hours plus two of the following:  Moderate to severe intensity  Unilateral symptoms  Throbbing, pulsating quality  Nausea, photophobia, and/or phonophobia  Aggravated by activity	Dietary trigger avoidance	Acute relief:  Nonsteroidal anti-inflammatory drugs  Triptans (frovatriptan [Frova], rizatriptan [Maxalt], sumatriptan [Imitrex], naproxen/sumatriptan [Treximet], zolmitriptan [Zomig] Preventive:  Angiotensin-converting enzyme inhibitor (lisinopril)  Angiotensin receptor blocker (candesartan [Atacand], telmisartan [Micardis])  Calcitonin gene-related peptide receptor inhibitors (erenumab [Aimovig], fremanezumab [Ajovy], galcanezumab [Emgality])  Magnesium (oral)  OnabotulinumtoxinA (Botox; only for chronic migraine [> 15 days per month])  Propranolol  Topiramate (Topamax)
Cluster	≥ 5 severe or very severe orbital or temporal headaches lasting 15 to 180 minutes and recurring every other day to 8 times per day plus either:  Ipsilateral autonomic features or  Restlessness/agitation	Preventive:  Noninvasive vagus nerve stimulation	Preventive:  Galcanezumab
General headache	Includes primary and secondary headache disorders	Aerobic exercise and progressive strength training Mindfulness-based therapy	Pharmacologic options are based on subtype