Medication	Comments
Calcimimetics*
Cinacalcet (Sensipar) Etelcalcetide (Parsabiv) Evocalcet (not available in the United States)	Decrease PTH Adverse effects: hypocalcemia, nausea May reduce need for parathyroidectomy in adults undergoing dialysis No effect on cardiovascular events, fractures, mortality
Calcium supplements
Calcium carbonate Calcium citrate Calcium gluconate	Increase serum calcium
Phosphate binders
Calcium based  Calcium acetate (21% elemental calcium)  Calcium carbonate (40% elemental calcium) Non–calcium based  Lanthanum (Fosrenol)  Sevelamer	Decrease serum phosphorus, PTH Adverse effects: hypercalcemia (calcium-based medications), kidney stones (calcium-based medications), gastrointestinal upset (lanthanum, sevelamer), constipation (sevelamer), metabolic acidosis (sevelamer hydrochloride) No effect on cardiovascular events, stroke, fracture, mortality Higher cost (non–calcium-based medications)
Vitamin D analogues
Calcifediol (25-hydroxycholecalciferol) Calcitriol (1,25-dihydroxy-cholecalciferol; Rocaltrol) Doxercalciferol (1alpha-hydroxyergocalciferol; Hectorol) Paricalcitol (1alpha-hydroxyergocalciferol; Zemplar)	Increase serum calcium and phosphorus Decrease PTH and bone resorption Not shown to cause hypercalcemia
Vitamin D supplements
Cholecalciferol (D3) Ergocalciferol (D2)	Increase 25-hydroxyvitamin D and serum calcium