Clinical Question

What is the best topical treatment for patients with mild to moderate acne vulgaris?

Bottom Line

For patients with mild to moderate acne, this network meta-analysis suggests starting with adapalene/benzoyl peroxide (Epiduo), clindamycin plus benzoyl peroxide (Neuac), or adapalene (Differin) alone. Patients who do not tolerate either combination containing benzoyl peroxide are likely to tolerate adapalene alone. (Level of Evidence = 1a)

Synopsis

An interdisciplinary team of U.K. researchers began by asking patients with acne what was most important to them in a study of acne treatments. The patients stated that self-reported improvement was more important than investigator-reported outcomes. Thus, the primary outcomes of this study were the proportion of patients who reported moderate or better improvement, and the proportion who withdrew from the study or stopped using the medication due to adverse events. This network meta-analysis identified 40 randomized trials evaluating 12 topical agents or topical combinations in 18,089 patients; 79% of the studies were from North America or Europe. Only studies that reported acne severity, and in which fewer than one-half of patients had severe acne, were included. The studies were a mix of an active drug vs. vehicle cream, or an active drug vs. a different active drug. A network meta-analysis reports a meta-analysis of direct comparisons and a meta-analysis of direct and indirect comparisons.