Minor criteria*

Respiratory rate† ≥ 30 breaths/min

PaO2/FiO2 ratio† ≤ 250

Multilobar infiltrates

Confusion/disorientation

Uremia (BUN level ≥ 20 mg/dL)

Leukopenia‡ (WBC count, < 4,000 cells/mm3)

Thrombocytopenia (platelet count, < 100,000 cells/mm3)

Hypothermia (core temperature, < 36°C)

Hypotension requiring aggressive fluid resuscitation

Major criteria

Invasive mechanical ventilation

Septic shock with need for vasopressors