Organism	Indication for treatment	First choice	Alternative
Campylobacter	All identified cases	Azithromycin (Zithromax)	Ciprofloxacin
Clostridioides difficile	All identified cases	Fidaxomicin (Dificid)*	Oral vancomycin
Giardia	All identified cases	Tinidazole (Tindamax), nitazoxanide (Alinia)	Metronidazole (Flagyl)
Nontyphoidal Salmonella enterica	Consider in patients older than 50 years with immunosuppression or significant joint or cardiac disease	Ceftriaxone, ciprofloxacin, TMP/SMX, amoxicillin	Not applicable
Non- Vibrio cholerae	Invasive disease only, including bloody diarrhea or sepsis	Ceftriaxone plus doxycycline	TMP/SMX plus aminoglycoside
Salmonella enterica typhi or paratyphi	All identified cases	Ceftriaxone or ciprofloxacin	Ampicillin, TMP/SMX, azithromycin
Shigella spp.	All identified cases	Azithromycin, ciprofloxacin, or ceftriaxone	TMP/SMX, ampicillin if susceptible
Vibrio cholerae	All identified cases	Doxycycline	Ciprofloxacin, azithromycin, ceftriaxone
Yersinia enterocolitica	All identified cases	TMP/SMX	Cefotaxime (Claforan), ciprofloxacin