brand logo

Am Fam Physician. 2022;106(2):193-194

Author disclosure: No relevant financial relationships.

A 40-year-old woman presented to the emergency department with a rash that began on her chest and spread to her extremities. She had a history of systemic onset juvenile idiopathic arthritis, chronic pain, and hypertension. Two weeks earlier, she was diagnosed with septic arthritis in her left knee that was treated with systemic ceftriaxone.

Physical examination showed a diffuse, pruritic, erythematous, maculopapular rash in a reticulated pattern (Figure 1). The patient responded well to high-dose oral steroids.


Based on the patient's history and physical examination findings, which one of the following is the most likely diagnosis?

  • A. Cutaneous manifestation of systemic onset juvenile idiopathic arthritis.

  • B. Drug-induced hypersensitivity reaction.

  • C. Small vessel vasculitis.

  • D. Stevens-Johnson syndrome.


The answer is B: drug-induced hypersensitivity reaction. This patient had a type IV hypersensitivity reaction, which appears four to 21 days after initiation of the causative medication. Although antibiotics are the most common inciting agents, nonsteroidal anti-inflammatory drugs, antiseizure medications, and chemotherapeutic agents have also been implicated. Risk factors include immunosuppression and viral infections in children.

Already a member/subscriber?  Log In


From $165
  • Immediate, unlimited access to all AFP content
  • More than 130 CME credits/year
  • AAFP app access
  • Print delivery available

Issue Access

  • Immediate, unlimited access to this issue's content
  • CME credits
  • AAFP app access
  • Print delivery available
Purchase Access:  Learn More

The editors of AFP welcome submissions for Photo Quiz. Guidelines for preparing and submitting a Photo Quiz manuscript can be found in the Authors' Guide at To be considered for publication, submissions must meet these guidelines. Email submissions to

This series is coordinated by John E. Delzell Jr., MD, MSPH, associate medical editor.

A collection of Photo Quiz published in AFP is available at

Continue Reading

More in AFP

More in PubMed

Copyright © 2022 by the American Academy of Family Physicians.

This content is owned by the AAFP. A person viewing it online may make one printout of the material and may use that printout only for his or her personal, non-commercial reference. This material may not otherwise be downloaded, copied, printed, stored, transmitted or reproduced in any medium, whether now known or later invented, except as authorized in writing by the AAFP.  See permissions for copyright questions and/or permission requests.