Chronic pain that persists or recurs for three months or more affects approximately one in five people and is more common in women, older people, veterans, Indigenous people (i.e., American Indian, Alaska Native, and Aboriginal Canadian), and those who are socioeconomically disadvantaged. Cannabis, or marijuana, is the source for tetrahydrocannabinol (THC) and cannabidiol (CBD), which with other cannabis derivatives are termed cannabinoids. Non-inhaled medical cannabis or cannabinoid products contain cannabis extract or combinations of cannabinoids, usually THC and CBD. Cannabinoids vary in pharmacologic action, which is mediated through the intrinsic endocannabinoid system.