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Am Fam Physician. 2022;106(2):208-209

This clinical content conforms to AAFP criteria for CME.

Author disclosure: No relevant financial relationships.

• Non-inhaled medical cannabis or cannabinoids can slightly improve pain and physical functioning for people living with chronic cancer or non-cancer pain.
• Non-inhaled medical cannabis or cannabinoids may lead to a small improvement in sleep quality.
• Medical cannabis and cannabinoids commonly cause transient dizziness and, less frequently, cognitive impairment, nausea, vomiting, drowsiness, and impaired attention.
From the AFP Editors

Chronic pain that persists or recurs for three months or more affects approximately one in five people and is more common in women, older people, veterans, Indigenous people (i.e., American Indian, Alaska Native, and Aboriginal Canadian), and those who are socioeconomically disadvantaged. Cannabis, or marijuana, is the source for tetrahydrocannabinol (THC) and cannabidiol (CBD), which with other cannabis derivatives are termed cannabinoids. Non-inhaled medical cannabis or cannabinoid products contain cannabis extract or combinations of cannabinoids, usually THC and CBD. Cannabinoids vary in pharmacologic action, which is mediated through the intrinsic endocannabinoid system.

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This series is coordinated by Michael J. Arnold, MD, Assistant Medical Editor.

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