Drug*	Adult dosing and cost†	Child dosing	Special considerations
Artemether/lumefantrine (Coartem)	One tablet is 20 mg/120 mg; four tablets per dose Three-day course (24 total tablets):  Day 1: initial dose followed by repeat dose eight hours later  Days 2 and 3: one dose every 12 hours  — ($130) for treatment course	One tablet is 20 mg/120 mg 5 kg to < 15 kg: one tablet per dose 15 kg to < 25 kg: two tablets per dose 25 kg to < 35 kg: three tablets per dose ≥ 35 kg: four tablets per dose Three-day course (number of tablets varies): same as adults	Take with high-fat foods for best absorption Crush and mix with 10 mL of water if unable to swallow tablets Repeat dose if vomiting occurs less than two hours after treatment
Atovaquone/proguanil (Malarone)	Four tablets once per day for three days (one adult tablet is 250 mg/100 mg) $25 ($90) for treatment course	One children's tablet is 62.5 mg/25 mg Daily dose taken for three days:  5 kg to < 8 kg: two children's tablets  8 kg to < 10 kg: three children's tablets  10 kg to < 20 kg: one adult tablet  20 kg to < 30 kg: two adult tablets  30 kg to < 40 kg: three adult tablets  ≥ 40 kg: four adult tablets	Consider alternative treatment in patients with severe renal impairment (creatinine clearance < 30 mL per minute per 1.73 m2 [0.50 mL per second per m2]) Take with food for best absorption Repeat dose if vomiting occurs less than one hour after treatment (less than 30 minutes for children) Crush and mix with water or milk if unable to swallow tablet Use for uncomplicated Plasmodium falciparum malaria acquired from countries with artemisinin resistance
Chloroquine	1 g salt (600 mg base) on day 1, followed by 500 mg salt (300 mg base) six, 24, and 48 hours after initial dose (total of four doses) $55 (—) for treatment course	16.7 mg salt (10 mg base) per kg on day 1, followed by 8.3 mg salt (5 mg base) per kg six, 24, and 48 hours after initial dose (total of four doses)	Only for treatment of nonsevere infections from regions with chloroquine sensitivity Do not use if chloroquine or hydroxychloroquine was used for prophylaxis
Hydroxychloroquine (Plaquenil)	800 mg salt (620 mg base) on day 1, followed by 400 mg salt (310 mg base) six, 24, and 48 hours after initial dose (total of four doses) $15 ($120) for treatment course	12.9 mg salt (10 mg base) per kg (maximum 800 mg per dose) on day 1, followed by 6.5 mg salt (5 mg base) per kg six, 24, and 48 hours after initial dose (total of four doses)	May be used in all trimesters of pregnancy
Quinine (Qualaquin) plus doxycycline, tetracycline, or clindamycin (Cleocin)	Quinine: 648 mg salt (542 mg base) three times per day for three to seven days; $40 ($130) for three-day treatment course Doxycycline: 100 mg twice per day for seven days; $10 (varies by brand) for treatment course Tetracycline: 250 mg four times per day for seven days; $40 (—) for treatment course Clindamycin: 20 mg per kg per day in three divided doses for seven days; $10 ($10) for treatment course in a patient weighing 70 kg	Quinine: 10 mg salt (8.3 mg base) per kg three times per day for three to seven days Doxycycline: 2.2 mg per kg twice per day for seven days Tetracycline: 25 mg per kg per day in four divided doses for seven days Clindamycin: 20 mg per kg per day in three divided doses for seven days	Administer quinine for three days unless infection occurred in Southeast Asia, in which case administer for seven days Doxycycline and tetracycline are favored over clindamycin but are not recommended during pregnancy or for children younger than eight years
Mefloquine	750 mg salt (684 mg base) on day 1, followed by 500 mg (456 mg base) six to 12 hours after initial dose (total of two doses) $15 (—) for treatment course	15 mg salt (13.7 mg base) per kg on day 1, followed by 10 mg salt (9.1 mg base) per kg six to 12 hours after initial dose (total of two doses) Do not exceed 500 mg per dose	Use only if no other treatment options are available Not recommended for infections acquired in Southeast Asia Associated with neuropsychiatric effects May be used in all trimesters of pregnancy