Condition	Effects	Selected treatments in pregnancy
Acne vulgaris 7	Worsens, especially in the second and third trimesters	Topical therapies: benzoyl peroxide, azelaic acid, antibiotics (erythromycin 2%, clindamycin 1%) Severe cases: oral antibiotics (e.g., erythromycin) or oral corticosteroids (e.g., prednisone at < 20 mg per day for ≤ 1 month) and procedural interventions (e.g., pulsed light therapy)
Condylomata acuminata8	Enlargement of lesions	Cryotherapy, laser therapy Extensive or refractory cases: imiquimod, surgical excision
Herpes simplex9	Of those with a history of recurrent genital herpes simplex, 75% have an outbreak during pregnancy	Suppressive antiviral therapy with acyclovir or valacyclovir at 36 weeks of gestation Cesarean delivery if there are active genital lesions or prodromal symptoms at time of labor
Hidradenitis suppurativa 10,11	Improves in pregnancy: 24% Worsens in pregnancy: 20% Worsens postpartum: 60%	Topical benzoyl peroxide, clindamycin 1% solution, oral antibiotics (e.g., cephalexin, amoxicillin/clavulanate, clindamycin, metronidazole [Flagyl], rifampin) Severe cases: intralesional corticosteroids (e.g., triamcinolone), laser-based treatment, surgical excision, TNF inhibitors
Pityriasis rosea 12–14	More common in pregnancy Higher miscarriage rate with onset earlier in pregnancy	Supportive care
Psoriasis 15–17	Usually improves in pregnancy and worsens postpartum	Emollients and low- to midpotency topical corticosteroids followed by ultraviolet B phototherapy Severe cases: TNF inhibitors, cyclosporine, systemic corticosteroids