Clinical recommendation	Evidence rating	Comments
A peripheral blood smear should be obtained in patients with hyperleukocytosis (white blood cell count of more than 100,000 per μL [100 × 109 per L]) and associated anemia, thrombocytopenia, thrombocytosis, hepatosplenomegaly, lymphadenopathy, or unexplained constitutional symptoms.14,19,20,22	C	Expert opinion and consensus guideline in the absence of clinical trials
Asymptomatic, early-stage chronic lymphocytic leukemia (i.e., absence of anemia or thrombocytopenia and less than three areas of lymph node involvement) may be monitored without treatment.4,19	C	Expert opinion and consensus guideline in the absence of clinical trials
Patients with leukemia who have neutropenic fever (i.e., less than 500 neutrophils per μL [0.5 × 109 per L]) should be evaluated for an infectious source with prompt initiation of empiric broad-spectrum antibiotics.27	C	Expert opinion and consensus guideline in the absence of clinical trials
Because of the potential for possible interactions between small-molecule inhibitors and commonly prescribed medications, a detailed medication review is recommended.24	C	Expert opinion and consensus guideline in the absence of clinical trials
Patients who have survived leukemia should receive routine age- and sex-specific cancer screening and periodic complete blood count monitoring.16–19,24,27,30,32,33	C	Expert opinion and consensus guideline in the absence of clinical trials